Editor’s highlights from the Journal of Comparative Effectiveness Research – May 2023

Written by Laura Dormer, Editor

In this monthly column, I share some of my highlights from the latest issues of the Journal of Comparative Effectiveness Research, partner journal of The Evidence Base.


It’s a pleasure to announce the publication of the May issue of the Journal of Comparative Effectiveness Research (Volume 12, Issue 5), this month including our regular Industry Update from Sreeram Ramagopalan, along with a protocol article on a statewide mobile addiction program and a systematic review of thrombectomy stent retrievers.


R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 11

On of our most-read articles in March/April, authors Bray and Ramagopalan provide their regular update of real-world evidence (RWE) developments of relevance to HTA. In this installment, they highlight a study from the REPEAT initiative evaluating the reproducibility of real-world data studies, the publication of the HARPER Protocol Template developed by a joint ISPE/ISPOR taskforce, and discuss recent US FDA guidance on external control arms.

You can also view the author’s additional thoughts on The Evidence Base here.

Read the full article here


Protocol for the implementation of a statewide mobile addiction program

In 2020, deaths due to opioid-related overdose claimed the lives of nearly six individuals a day in MA, USA. In this protocol paper, authors Tschampl et al. describe the Community Care in Reach® (CCiR) model, which uses a mobile unit to bring both harm reduction and clinical care for addiction to people experiencing barriers to office-based care. In the paper the authors outline an analysis that uses the RE-AIM framework to measure the impact of the CCiR model on its target population, as well as the experience of the program staff in its implementation.

Read the full article here


MASTRO I: Meta-Analysis and Systematic Review of thrombectomy stent retriever outcomes: comparing functional, safety and recanalization outcomes between EmboTrap, Solitaire and Trevo in acute ischemic stroke

Stent-retriever (SR) thrombectomy has demonstrated superior outcomes in patients with acute ischemic stroke compared with medical management alone, but differences among SRs remain unexplored. In another highly read article from March/April, Zaidat et al. systematically reviewed studies reporting stroke outcomes with three commonly used SRs to combine and compare outcomes.

Read the full article here


Do also check out the rest of the content for the May issue, which I hope you enjoy. As ever, get in touch if you have any queries about the journal, or are interested in contributing to a future issue.