Comparative and combined effectiveness of innovative therapies in cancer: a literature review

In this article, the authors examine the results of clinical trials assessing so-called "innovative therapies". This systematic review, from the Journal of Comparative Effectiveness Research, is free to access exclusively for The Evidence Base® members. To achieve therapeutic innovation in oncology, already expensive novel medicines are often concomitantly combined to potentially enhance effectiveness. While this aggravates the pricing problem, comparing effectiveness of novel yet expensive (concomitant) treatments is much needed for healthcare decision-making to deliver effective but affordable treatments.This study, by researchers from KU Leuven (Belgium) and the University of Georgia (GA, USA), reviews published clinical trials and real-world studies of targeted...