Is KI67 prognostic for aggressive prostate cancer? A multicenter real-world study

In this research article, published in Biomarkers in Medicine, researchers sought to determine if KI67 expression could be prognostic for biochemical recurrence after radical prostatectomy. Differentiating between indolent and aggressive prostate cancer is critical to optimal disease management. Since all therapies carry some risks that may encompass life altering morbidity, good prognostic biomarkers are needed to identify patients who could benefit from aggressive management.KI67 is a well-studied protein exclusively expressed in proliferating cells throughout all cell cycle phases, except for the resting phase. This allows for quick, easy and cost-effective determination of the ‘growth-fraction’ of cells. This property of KI67...