Organized structure of real-world evidence best practices: moving from fragmented recommendations to comprehensive guidance

Summary

Decision-makers have become increasingly interested in incorporating real-world evidence into their decision-making process. Stakeholders have issued numerous recommendation documents, due to concerns regarding the reliability and quality of real-world evidence, to assist in setting real-world evidence standards. However, the fragmented nature of these documents poses a challenge to researchers and decision-makers.

In this Perspective article, authors affiliated with Aetion Inc. (NY, USA), Amgen Inc. (CA, USA), the National Institute for Health and Care Excellence (Manchester, UK) and the European Medicines Agency (Amsterdam, The Netherlands) offer researchers and decision-makers a structure to organize the landscape of real-world evidence recommendations and identify consensus and gaps in the current recommendations.