Efficacy classification of modern therapies in multiple sclerosis

Summary

The Association of British Neurologists’ (London, UK) 2015 guidelines suggested classifying multiple sclerosis therapies according to their average relapse reduction. In this study, researchers sought to classify newer therapies (cladribine, ocrelizumab, ofatumumab, ozanimod) based on these guidelines.

Therapies were classified by using direct comparative trial results, and generating classification probabilities for each therapy based on comparisons versus placebo in a network meta-analysis for annualized relapse rate. For both approaches, cladribine and ofatumumab were classified as high efficacy. Ocrelizumab and ozanimod (1.0 mg) were classified as moderate or high efficacy depending on the approach used.