Is adjuvant chemotherapy effective for individuals with breast cancer who are poorly represented in traditional clinical trials?

Researchers have employed real-world administrative healthcare data to retrospectively estimate the effectiveness of adjuvant chemotherapy for individuals with early-stage breast cancer who are poorly represented in clinical trials, such as those with greater comorbidities. A previous meta-analysis of nearly 200 randomized controlled trials demonstrated that adjuvant chemotherapy — chemotherapy administered alongside another main cancer treatment with the intention of enhancing the efficacy of the main treatment — led to reduced patient mortality amongst individuals with early-stage breast cancer. However, the effectiveness of this therapeutic approach has been less well evaluated amongst individuals poorly represented in clinical trials, such as those...