Can appendectomies cause Parkinson's disease? Abstract highlights from day 3 of ISPOR Europe 2019
As part of our continuous coverage of the ISPOR Europe 2019 (2–6 November; Copenhagen, Denmark) meeting, we bring you our abstract highlights from the third and final day of the conference: Parkinson's disease, multiple sclerosis and more!
Following recent suggestions that appendectomy surgeries can increase individuals’ risks of developing Parkinson’s disease (PD), researchers from The University of Tokyo and Milliman Inc. (both Tokyo, Japan) have conducted a US claims database review of 13,951 individuals with PD who underwent appendectomies and compared their outcomes to 13,927 matched control persons with PD, who underwent no, or other, surgeries.
The results of the study demonstrate no statistically significant association between patients’ undergoing appendectomy surgery and having increased, or reduced, likelihood of developing PD.
Relapse frequency is a well-regarded parameter from which to assess the real-world efficacies of disease-modifying therapies for multiple sclerosis. In this study, led by researchers from Bordeaux University (France), a novel algorithm for detecting relapse frequencies based on claims data was applied to the French nationwide claims database (SNIIRAM/SNDS).
The claims-based algorithm was found to successfully identify patients with and without relapses with at least 95% accuracy. The results of the study therefore demonstrate the potential of applying such technology in future observational, claims-based studies.
Outcomes-based agreements are being increasingly implemented to address uncertainty surrounding the value delivered by medical devices. As a result, it has become ever more important to evaluate the associated outcomes-risks pf these agreements. In a novel study, an international team of Johnson & Johnson Medical researchers from the Netherlands, France and the USA have applied basic statistical principles to the risk evaluation of outcomes-based agreements. This study specifically focused on outcomes-based agreements aimed at reducing surgical-site infections.
The study highlights the importance of collaboration in developing and selecting appropriate and achievable outcomes-based agreements that are beneficial to all stakeholders, with risk transparency.