The road ahead: working towards effective clinical translation of biomedical HIV prevention strategies

In this review, researchers discuss the path ahead for the translation of new, scientifically proven, biomedical prevention strategies for HIV prevention into policy and practice. Emerging evidence from several randomized controlled trials show that antiretroviral-based biomedical HIV prevention interventions are efficacious in preventing HIV if they are taken as directed, and could potentially reduce the number of new HIV infections globally. Strategies such as treatment as prevention and use of oral pre-exposure prophylaxis for HIV prevention have shown great promise, yet have raised important implementation concerns around awareness and acceptance, delivery, adherence, side effects, risk compensation, cost—effectiveness and drug resistance....