Peek Behind the Paper: is high-dose baclofen use associated with increased risk of encephalopathy in individuals with chronic kidney disease?

Written by The Evidence Base

We 'Peek Behind the Paper' with lead study author Flory Muanda (Institute for Clinical Evaluative Sciences; ICES, Ontario, Canada) to further understand how researchers investigated the association between high-dose baclofen and encephalopathy in older individuals with chronic kidney disease (CKD). In 2019, we reported on the results of a novel study suggesting that individuals with chronic kidney disease prescribed a high dose of baclofen are more likely to be hospitalized for severe confusion or disorientation compared with individuals not prescribed the drug, or prescribed a low drug dose. In this feature, we peek behind the paper with lead study author...

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