Journal of Comparative Effectiveness Research Vol. Ahead of print No. | Abstracts

Real-world treatment patterns and outcomes in platinum-sensitive recurrent high-grade serous ovarian cancer patients

Summary

This research aimed to describe the overall cancer-related healthcare utilization patterns, treatment patterns and outcomes in women diagnosed with platinum-sensitive recurrent high-grade serous ovarian cancer. The study involved a subanalysis of the Spanish sample of a retrospective, noninterventional, multinational, observational study. It was found that BRCA-mutated patients had better outcomes in terms of progression-free survival and overall survival than patients who were BRCA wild-type. It was observed that patients’ treatment outcomes after the first recurrence progressively worsened as the patient underwent subsequent chemotherapy lines. Healthcare resource utilization when accounting for the follow-up time did not substantially differ between BRCA1/2-mutated and BRCA wild-type patients. In sum, BRCA1/2 mutation carriers have better treatment outcomes, including longer survival, without a negative impact on the use of healthcare resources.

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