Initial findings from RCT DUPLICATE initiative published

Published in Circulation, researchers have reported findings from ten real-world evidence studies that were designed to emulate randomized controlled trials (RCTs) evaluating cardiovascular outcomes associated with antidiabetic or antiplatelet medications, as part of the RCT DUPLICATE initiative. Jessica Franklin (Harvard Medical School and Brigham and Women’s Hospital, both MA, USA), RCT DUPLICATE Co-Lead, commented: “These findings bring us one step closer in our effort to build empirical evidence that informs how [real-world evidence] can support regulatory reviews across various treatment areas.” RCT DUPLICATE designs real-world evidence studies, using a structured process, to emulate RCTs and compare results; the initiative seeks...

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