Use of common antihypertensive medications not associated with increased risk of depression, study suggests

Researchers from the University of Copenhagen (Denmark) have analyzed Danish population-based registry data and determined that individuals’ use of one of 41 common medications for high blood pressure was not associated with their increased risk of depression.

Whilst depression can be common amongst individuals with high blood pressure and other cardiovascular conditions, new research, published in Hypertension, suggests use of antihypertensive medications is likely not responsible for this correlation.

In the study, data pertaining to more than 3.7 million individuals from Denmark who were taking one of 41 of the most common antihypertensive medications – as detailed in health records in Danish national registries from 2005–2015 – were analyzed. No association was observed between individuals’ use of any of the studied medications and their increased risk of depression. Nine of the medications – across various drug classes – were even found to be associated with reduced rates of depression.

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Kessing LV, Rytgaard HC, Ekstrøm CT, Torp-Pedersen C, Berk M, Gerds TA. Antihypertensive drugs and risk of depression. Hypertension. doi:10.1161/HYPERTENSIONAHA.120.15605 (2020) (Epub ahead of print);